About Human Growth Hormone
Amino Acids are the building blocks of proteins used to create hormones. Human Growth Hormone (HGH) is one of the largest and most fragile molecules in the body. It has 191 Amino Acids counstructed in a very specific fashion, intricately folded upon itself. Any change in its fold or amino acid sequence could make this hormone useless.
Human Growth Hormone is produced by the anterior pituitary gland, located near the brain. Like other endocrine hormones (estrogen, progesterone, melatonin, testosterone, and DHEA) it declines in production with age.
Daily growth hormone secretion diminishes as we age. A 60-year-old person may secrete 25% of the HGH secreted by a 20-year-old. Growth hormone is primarily released in pulses that take place during the beginning phase of sleep, and then is quickly converted in the liver to its powerful growth promoting metabolite, Insulin-Like Growth Factor Type 1 (IGF-1) also known as Somatomedin C. IGF-1 elicits most of the effects associated with human growth hormone and can be measured in the blood to determine the level of growth hormone secretion.
The decline of growth hormone with age, sometimes referred to as somatopause, is directly associated with many of the symptoms of aging, including wrinkling, gray hair, decreased energy and sexual function, increased body fat, cardiovascular disease, osteoporosis and more. Many of these symptoms have been associated with younger adults who have a growth hormone deficiency. The biological age of these adults has surpassed chronological age. HGH may be able to reverse these symptoms.
Human Growth Hormone or HGH was first discovered in the 1920's. In 1958, Maurice Raben at the New England Medical Center in Boston was the first physician to inject HGH into a child who had none in order to stimulate the growth of their short stature. This caused the child to grow normally. The source of this HGH was from the pituitary gland of the cadavers. Although this was a successful treatment for the growth of children who would otherwise be dwarfs from anterior pituitary failure and its lack of HGH, the FDA ordered the HGH distribution to be stopped in the 1980's due to Crestzfeldt-Jakob Disease.
Genentech was the first company to biosynthetically clone HGH.
Research done in Denmark and Sweden showed that replacing HGH through injections in deficient adults improved lean body mass. Dr. Daniel Rudman, an endocrinologist, speculated that HGH hormonal replacement may be able to retard or even reverse aging based upon this fact and that Human Growth Hormone decline was very significant after age 35. This decline is also accompanied by changes in lean body mass as well as other symptoms associated with aging.
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