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 Study: Association Between Growth
 Factorand Bone Mineral Density
 in Older Women and Men

The Framingham Heart Study

Jean A. Langlois, Clifford J. Rosen, Marjolein Visser, Marian T. Hannan, Tamara Harris, Peter W. F. Wilson and Douglas P. Kiel

Address all correspondence and requests for reprints to: Jean A. Langlois, Division of Acute Care, Rehabilitation Research, and Disability Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, 4770 Buford Highway, NE (MS F-41), Atlanta, Georgia 30341-3724. E-mail: JAL7@CDC.GOV.

OSTEOPOROTIC fracture remains one of the most important causes of hospitalization, lost independence, and death among older women and men, and a wide range of treatments for osteoporosis are currently being developed.

Although antiresorptive therapies that reduce bone loss are now in use, interventions using anabolic agents await improved understanding of the role of factors that control the formation of bone.

bone densityThe hypothesis that a deficiency in GH and insulin-like growth factor I (IGF-I) is a major cause of aging, and that restoration of the GH-IGF-I axis may prevent age-related decline, including bone loss, has received considerable scientific and public attention.

One of the most abundant growth factors present in bone, IGF-I has been shown to stimulate bone formation. Declines in skeletal and serum IGF-I levels with age parallel decreases in bone mass with age, suggesting a relationship between decreased IGF-I levels and age-related bone loss.

Few studies of the GH axis and bone have focused specifically on elderly people. Some have found no relationship between IGF-I and bone mineral density (BMD), and the few reports of an association between serum IGF-I levels and BMD may have overestimated the association by not accounting for factors such as weight loss and protein intake that can influence both IGF-I level and BMD.

The objective of this study was to determine the cross-sectional association between IGF-I and BMD in very old women and men from the Framingham Heart Study.


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